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Planta Med 2010; 76(14): 1605-1610
DOI: 10.1055/s-0029-1241014
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Arisanschinins A–E, Lignans from Schisandra arisanensis Hay.

Chin-Cheng Liu1 , Mohamed H. Abd El-Razek1 , Chia-Ching Liaw1 , Yuan-Bin Cheng1 , Chien-Kuang Chen1 , Ching-Te Chien2 , Yao-Haur Kuo3 , Shorong-Shii Liou4 , Ya-Ching Shen1
  • 1School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
  • 2Division of Silviculture, Taiwan Forestry Research Institute, Taipei, Taiwan
  • 3National Research Institute of Chinese Medicine, Taipei, Taiwan
  • 4Department of Pharmacy, Tajen University, Ping Tung, Taiwan
Further Information

Publication History

received October 12, 2009 revised February 22, 2010

accepted February 24, 2010

Publication Date:
22 March 2010 (online)

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Abstract

Four new oxygenated dibenzocyclooctadiene lignans, arisanschinins A–D (1–4), and a new 1,4-bis(phenyl)-2,3-dimethylbutane lignan, arisanschinin E (5), together with 15 known compounds, were isolated from the EtOAc-soluble fraction of the aerial parts of Schisandra arisanensis Hay. The structures of 1–5 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments. The configurations of the biphenyl and octadiene moieties were deduced from circular dichroism (CD) and NOESY spectra, respectively. Compound 1 showed significant inhibition of α-glucosidase in vitro. The radical-scavenging activities of these compounds were evaluated using DPPH.

Key words

Schisandraceae - Schisandra arisanensis - lignans - dibenzocyclooctadiene - α‐glucosidase inhibition

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Prof. Ya-Ching Shen

School of Pharmacy
College of Medicine
National Taiwan University

12F, No. 1, Sec.1, Jen-Ai Rd.

100 Taipei

Taiwan, Province of China

Phone: + 88 62 23 12 34 56 ext. 6 22 26

Fax: + 88 6 02 23 91 90 98

Email: ycshen@ntu.edu.tw

    www.thieme-connect.de/ejournals/toc/plantamedica