Planta Med 2009; 75 - PJ44
DOI: 10.1055/s-0029-1234849

Anti-inhibitory effect of eupatilin and jaceosidin from Artemisia princeps Pampini

SW Min 1, NJ Kim 2, NI Baek 3, DH Kim 1
  • 1Department of Life and Nanopharmaceutical Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul 130–701, Korea
  • 2Institute of East and West Medical Research, Kyung Hee University, Seoul 130–702, Korea
  • 3Graduate School of Biotechnology and PMRC, Kyung Hee University, Suwon 449–701, Korea

Main constituents, eupatilin and jaceosidin from Artemisia princeps Pampanini (family Asteraceae), which is widely used as a hepatoprotective, antioxidative, anti-inflammatory, and antibacterial agent, in a herbal medicine, were isolated and their inhibitory effects against carrageenan-induced inflammation in air pouch prepared in the back of mice were investigated [1–3]. These constituents significantly reduced inflammatory markers, leukocyte number and protein increased by carrageenan in the exudates of air pouch. These constituents did not only inhibited cyclooxygenase-2 expression and nuclear factor-kappa B activation by immunoblot analysis, but also markedly reduced tumor necrosis factor-α and prostaglandin E2 levels by enzyme-linked immunosorbent assay. Eupatilin and jaceosidin also inhibited hind paw edema induced by carrageenan. These findings suggest that eupatilin and jaceosidin potently express anti-inflammatory effect by the inhibition of transcription factor nuclear factor-kappa B activation.

Reference: [1] Kim, S.H. et al. (1997) Res. Commun. Mol. Pathol. Pharmacol. 97:165–170.

[2] Park, S.C. et al. (2006)J. Gastroenterol. 41:772–778.

[3] Kim, J.Y. et al. (2005)J. Toxicol. Environ. Health A 68:2063–2080.