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DOI: 10.1055/s-0029-1234835
Raunitidine isolated from Duroia macrophylla (Rubiaceae)
Duroia macrophylla Huber is a tropical tree, known as „puruí“, which occurs in the Amazon region. Their fruits can be eaten and, as we know, no chemical study has been performed before. Leaves of D. macrophylla were dried at room temperature, ground and extracted with dichloromethane, methanol and later with water, by using ultra-sound for 20 minutes, each twice repeated and concentrated with reduced-pressure evaporator or liophylizer. The methanolic extract was fractioned by using chromatographic techniques and HPLC for further purification. The chemical identification of the indolic alkaloid raunitidine was achieved by NMR and MS data analyses and literature comparison [1].
Acknowledgements: PPBio/INPA/MCT; CNPq; FAPEAM.
References: [1] Merlini, L. et al. (1976) Helv. Chim. Acta 59:2254–2260.