Planta Med 2009; 75 - PI36
DOI: 10.1055/s-0029-1234800

In vitro evaluation of antioxidant, antibacterial, anti-tyrosinase activities of Zanthoxylum planispinum

SJ Hwang 1, SC Pak 2
  • 1Department of Biology, College of Natural Sciences, Chonnam National University, Gwang-ju 500–757, S. Korea
  • 2School of Biomedical Sciences, Charles Sturt University, Bat, Australia

The methanolic extracts of Zanthoxylum planispinum leaves from south Korea were screened for their antioxidant properties, tyrosinase inhibition and antibacterial activities to apply as a functional ingredient for cosmetic products. The level of total phenolics and flavonoids of the leaves extracts were determined by UV/VIS spectroscopy. The extract of Zanthoxylum planispinum leaves had good phenolic (391mg/g) and flavonoid (187mg/g) contents and showed strongest activity of antioxidant-related enzymes including SOD, CAT, and APX. IC50 value of the extracts against mushroom tyrosinase was 5.3µg/ml which is about 5 times more effective than arbutin and kojic acid. RS50 value of the DPPH free radical scavenging activity of the extracts was 2.7µg/ml which is about 3 times more effect than BHT and α-tocoperol. The extracts also showed the best antimicrobial activity from gram-negative bacteria to gram-positive bacteria with MID value as low as 20µg/disc.

References: [1] Dewck, A.C. (2009) Clin. Dermatol. 27:148–158.

[2] Kivrak, I. et. al. (2009) Food Chem. 116:470–479.

[3] Larson, R.A. (1988) Phytochemistry 27:969–978.