Planta Med 2009; 75 - PE56
DOI: 10.1055/s-0029-1234617

A new phenolic glycoside from the stems of Clematis parviloba

LH Yan 1, 2, AH Brantner 4, ZM Wang 2, QW Zhang 2, LZ Xu 1, SL Yang 3
  • 1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, North Malianwa Road, Beijing 100094, P. R. China
  • 2Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, P. R. China
  • 3National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, No. 56, Yangming Road, Nanchang 330006, P. R. China
  • 4Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens University Graz, Universitaetsplatz 4/1, 8010 Graz, Austria

A new phenolic glycoside, clemaparviloside A (1) together with three known megastigmane glycosides, linarionoside A (2), linarionoside C (3) and staphylionoside K (4) were isolated from the stems of Clematis parviloba [1,2]. Their structures were determined on the basis of spectroscopic analysis and chemical evidence. The megastigmane glycoside compounds are reported for the first time to be obtained from Clematis genus. In addition, compound 1 was examined its inhibitory activity against murine fibrosarcoma L929 cells in vitro.

References: [1] Hideaki, O. (1994) Phytochemistry 37:461–465.

[2] Qian, Y. et al. (2005) Chem. Pharm. Bull. 53:800–807.