Bioactive phenolic compound from Hymenocrater calycinus

M Malmir; AR Gohari; S Saeidnia; F Moradi-Afrapoli; N Yassa; AR Shahverdi; K Mollazadeh; A Hadjiakhoondi

doi:10.1055/s-0029-1234555

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Planta Med 2009; 75 - PD76
DOI: 10.1055/s-0029-1234555

Bioactive phenolic compound from Hymenocrater calycinus

M Malmir ¹, AR Gohari ¹, S Saeidnia ¹, F Moradi-Afrapoli ², N Yassa ¹^,², AR Shahverdi ³, K Mollazadeh ³, A Hadjiakhoondi ¹^,²

¹Medicinal Plants Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran, P O Box 14155–6451, Tehran, Iran
²Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran
³Department of Pharmaceutical Biotechnology and Pharmaceutical Biotechnology Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran

Kongressbeitrag

Four compounds were isolated from ethyl acetate and methanol extracts of the flowered aerial parts of Hymenocrater calycinus (Lamiaceae) using chromatographic methods and identified by spectroscopic data (MS, ¹H- and ¹³C-NMR, HMQC, HMBC and ¹H-¹H COSY). Antifungal and antibacterial effects of rosmarinic acid, the main component, were determined against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger within the broth dilution method.

Isolated compounds were identified as β-sitosterol (1), ursolic acid (2), rosmarinic acid (3) and quercetin 3–0- rutinoside (4) for the first time in Hymenocrater genus. The results of our assay against bacteria and fungi represent that rosmarinic acid has an antifungal property against Candida albicans (MIC, 250µg/ml).