Planta Med 2009; 75 - PD67
DOI: 10.1055/s-0029-1234546

Stilbenoids constituents in Welwitshia mirabilis 2

I Iliya 1, 2, H Murata 3, T Ito 1, M Oyama 1, K Matsumoto 4, Y Akao 4, T Tanaka 1, I Munkazu 1, Y Nozawa 4
  • 1Gifu Pharmaceutical University, 5–6-1 Mitahora Higashi, Gifu 502–8585, Japan
  • 2National Institute for Pharmaceutical Research and Development, Abuj, 900001, Nigeria
  • 3Faculty of Pharmaceutical Sciences, Setsunan University, 45–1 Nagaote-cho, Hirakata, Osaka 573–0101, Japan
  • 4Gifu International Institute for Biotechnology, 1–1 Naka-Fudogaoka, Kakamigahara 504–0838, Japan

Welwitschia mirabilis is an endangered and unique gymnosperm of Namib Desert of South West Africa. It is a monotypic member of the Genus Wellwitschia. In our previous work we have reported the isolated and identification of sevaral stilbenoids from a cultivated W. Mirabilis. In the present study we report the isolation and structure elucidation of five new stilbene derivatives including the first incidence of a stilbene pentamer from the family. The structures of the new compounds were assigned by spectroscopic analysis. The apoptotic activities of the stilbenoids were also investigated.1

References: [1] Iliya, I. et al. (2006) Biol. Pharm. Bull. 29(7):1490–1492.