Planta Med 2009; 75 - PD56
DOI: 10.1055/s-0029-1234535

Antioxidant and hepatoprotective activities of terpenoids isolated from Salvia multicaulis Vahl

M Abd El-Mohsen 1, M Spencer 2, N Ehsan 3, A Hussein 1, F Hammouda 1, M Hifnawy 4, S Ismail 1
  • 1Department of Phytochemistry, National Research Center, Cairo, Egypt
  • 2University of Reading, Reading, UK
  • 3National Liver Institute, Monfia, Egypt
  • 4Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt

Salvia multicaulis is a perennial shrub belonging to family Lamiaceae [1]. Candesalvone A, candesalvone B, with two triterpenes have been isolated from the aerial parts, the structure was elucidated by means of spectral data [2].

The isolated compounds were tested for their antioxidant and hepatoprotective activities [3,4]. Almost all the compounds (at 25–40µg/ml) provoked significant hepatoprotection (95%), comparable to silymarin (98%). The diterpenoids (A, B) exhibited strong antioxidant activity (92%), compared to Trolox (97%), while the triterpenoid compounds showed only negligible activity (70%).

References: [1] Boulos, L. (2000) Flora of Egypt. 3:12.

[2] Abd El-Mohsen, M. (2007) Ph D Thesis, Pharmacognosy Dept., Faculty of Pharmacy, Cairo University, Egypt .

[3] Cai, Y. et al. (2004) Life Sci. 74:2157–2184.

[4] Kiso, Y. et al (1983)J. Nat. Prod. 46:841–847.