Field study into the efficacy of a medicinal plant based complex for management of Equine Cushings Syndrome in ageing horses

Pituitary Pars Intermedia Dysfunction (PPID), known as Equine Cushings Syndrome, is characterized by elevated plasma glucocorticoid concentration due to adenoma or hyperplasia of the pars intermedia of the pituitary gland. Clinical signs include hirsutism, hyperhidrosis, muscle atrophy, chronic infections, polyuria, polydipsia and laminitis [1]. The dopamine agonist pergolide mesylate is the conventional therapy of choice. Compliance is poor due to expense, poor prognosis and adverse events [2].

The AIM of this study was to assess effectiveness of a medicinal plant complex based on, though not exclusively, Vitex agnus-castus and Gynostemma pentophyllum, chosen for their traditional use in PPID and associated laminitis. Anti-ageing herbs, Gingko biloba and Panax ginseng are also included for mental acruity. METHODOLOGY: Owners of PPID affected horses completed a questionnaire prior to and following supplementation with a medicinal plant based complex. Results: Seven animals, mean age 24.71yrs, were tested. Following one month supplementation a significant (p<0.05) improvement was seen in Body condition, Coat condition and Alertness. Improvement approaching significance (p<0.1) was seen in Lameness, Sweating and Thirst. CONLCUSION: PPID is a relatively common, progressive problem of ageing horses where quality of life is paramount. The plant based complex can improve quality of life for PPID affected horses, providing owners with an acceptable and economical long term management alternative to conventional drug therapy.

References: [1] Harman, J., Ward, M. (2001) Altern. Med. Rev. 6: Suppl:S4-S16.

[2] Sojka, J. (2009) Current Therapy in Equine Medicine. ed Robinson, N.E. and Sprayberry, K.M. Pub: Saunders.