Planta Med 2009; 75 - PD4
DOI: 10.1055/s-0029-1234483

Trypanocidal activity of pterogynidine and nitensidine E using two distinct Trypanosoma cruzi strains

MC Siqueira 1, MTA Silva 1, LO Regasini 2, DHS Silva 2, RMB Cicarelli 1
  • 1Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista – UNESP, Rodovia Araraquara-Jau, km01, CP 502, 14801–902, Araraquara, SP, Brasil
  • 2Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais – NuBBE, Instituto de Química – Universidade Estadual Paulista – UNESP, R. Francisco Degni, s/n, CP 355, 14801–970, Araraquara, SP, Brasil

Pterogynidine (1) and Nitensidine E (2) were isolated from different parts of Pterogyne nitens, which is a native tree common in South America [1,2]. Recently, Regasini et al. [3] demonstrated that nitensidine E was the most active compound against different tumor cell lines, while pterogynidine was inactive. The structure of nitensidine E is the first report of natural occurrence of a cyclic monoterpene derivative on a guanidine moiety [3].

(1)

(2)

We described the trypanocidal activity of both compounds and IC50 values (µg/ml) were determined as follows: pterogynidine: 22.5 (Y strain) and <0.07 (BOL strain); nitensidine E: 2.41 and 3.00, respectively, demonstrating a higher correlation between the number of prenyl units and the trypanocidal activity.

Acknowledgements: FAPESP (2004/07932–7; 2007/02076–3; 2008/06021–1); CAPES.

References: [1] Lorenzi, H. (1998) Plantarum. Nova Odessa, Brasil.

[2] Bukart, A. (1952) Aemé Agency. Buenos Aires, Argentina.

[3] Regasini, L.O. et al. (2009)J. Nat. Prod. 72:473–476.