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DOI: 10.1055/s-0029-1234483
Trypanocidal activity of pterogynidine and nitensidine E using two distinct Trypanosoma cruzi strains
Pterogynidine (1) and Nitensidine E (2) were isolated from different parts of Pterogyne nitens, which is a native tree common in South America [1,2]. Recently, Regasini et al. [3] demonstrated that nitensidine E was the most active compound against different tumor cell lines, while pterogynidine was inactive. The structure of nitensidine E is the first report of natural occurrence of a cyclic monoterpene derivative on a guanidine moiety [3].
We described the trypanocidal activity of both compounds and IC50 values (µg/ml) were determined as follows: pterogynidine: 22.5 (Y strain) and <0.07 (BOL strain); nitensidine E: 2.41 and 3.00, respectively, demonstrating a higher correlation between the number of prenyl units and the trypanocidal activity.
Acknowledgements: FAPESP (2004/07932–7; 2007/02076–3; 2008/06021–1); CAPES.
References: [1] Lorenzi, H. (1998) Plantarum. Nova Odessa, Brasil.
[2] Bukart, A. (1952) Aemé Agency. Buenos Aires, Argentina.
[3] Regasini, L.O. et al. (2009)J. Nat. Prod. 72:473–476.