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DOI: 10.1055/s-0029-1224867
Comparison of Urinary Cytokines after Ingestion of Cranberry Juice Cocktail in Pregnant Subjects: A Pilot Study
Publication History
Publication Date:
26 June 2009 (online)
ABSTRACT
Our objective was to evaluate urinary cytokine excretion after daily cranberry or placebo exposure in pregnant women. Four-hour urine samples were collected from 27 pregnant women subjects who were randomized to cranberry juice cocktail or placebo in three treatment arms: A: Cranberry (C) two times daily (C, C; n = 10 pregnant); B: cranberry in the am, then placebo (P) in the pm (C, P; n = 9 pregnant); and C: placebo two times daily (P, P; n = 8 pregnant). Urinary cytokines were measured using commercially available kits. There was a statistically significant difference in interleukin (IL)-6 of the urinary cytokines between the multiple daily cranberry dosing group (group A [C, C]): median, 3.16 (range, 0.01 to 7.34) and the placebo group (group C [P, P]): 9.32 (0.53 to 29.61 pg/mL; p = 0.038, Kruskal-Wallis test). We concluded that a difference in IL-6 was found in the multiple daily cranberry dosing groups compared with placebo. Lack of differences based on treatment allocation in the other cytokines may be due to β error. Further studies are planned to evaluate these assays for the assessment of clinical effect.
KEYWORDS
Cranberry - urinary tract infection - cytokines
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Deborah A WingM.D.
Department of Obstetrics-Gynecology, 101 The City Drive South
Building 56, Suite 800, Orange, CA 92868; reprints not available from the author
Email: dwing@uci.edu