Am J Perinatol 2009; 26(8): 597-600
DOI: 10.1055/s-0029-1220781
© Thieme Medical Publishers

Warfarin-Associated Fetal Intracranial Hemorrhage in Woman with Mitral Valve Replacements: A Case Report

Hitoshi Masamoto1 , Hiroyuki Uehara1 , Keiko Mekaru1 , Tadakazu Uezato1 , Kaoru Sakumoto1 , Yoichi Aoki1
  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
Further Information

Publication History

Publication Date:
29 April 2009 (online)

ABSTRACT

Warfarin-associated fetal hemorrhage is a fatal event. We report the case of a 39-year-old woman who had been taking warfarin for 23 years since undergoing mitral valve replacement. Thereafter, when she was found to be pregnant, the medication was switched to heparin from 6 to 21 weeks of gestation. Following this, she was prescribed oral warfarin again (3.5 mg per day), with a strict control of prothrombin time/international normalized ratio (PT/INR). At 23 weeks of gestation, fetal intracranial hemorrhage occurred because of maternal exposure to warfarin. Maternal PT/INR does not correlate well with the activity of warfarin in the fetus and currently, there is no direct way to prevent fetal intracranial hemorrhage. Hence, further research on the optimal coagulation therapy in pregnant women with valve replacement should be encouraged.

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Yoichi AokiM.D. 

Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus

207 Uehara, Nishihara, Okinawa 903-0215, Japan

Email: yoichi@med.u-ryukyu.ac.jp