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Semin Thromb Hemost 2009; 35(2): 181-188
DOI: 10.1055/s-0029-1220326
© Thieme Medical Publishers

Diagnostic Evaluation of Platelet Function Disorders in Neonates and Children: An Update

Sara J. Israels1 , 2 , 3
  • 1Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
  • 2The Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
  • 3Haemostasis Laboratory, Health Sciences Centre, Winnipeg, Manitoba, Canada
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Publikationsverlauf

Publikationsdatum:
30. April 2009 (online)

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ABSTRACT

Investigation of platelet function disorders in infants and small children requires the collaborative efforts of clinicians and clinical laboratories. A detailed personal, family, and medication history, and a search for additional clinical phenomena may help to direct diagnostic laboratory investigations. Testing for these disorders in young children presents several challenges: the requirement of relatively large volumes of blood, lack of standardization, and the absence of well-established age-specific reference ranges. Neonates show the most notable differences in platelet function compared to older children and adults; the decreased platelet activation responses persist for the first 2 to 4 weeks after delivery. Small studies of normal postneonatal pediatric populations have provided data on platelet function assays, including bleeding times, PFA-100 closure times, thromboelastography, aggregation, secretion, and flow cytometry. The majority of these studies, comparing normal children with adults, found only minor differences in platelet responses measured by these assays.

KEYWORDS

Platelet function - platelet disorders - platelet aggregation - newborn - child

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Dr. Sara J Israels

Pediatric Hematology/Oncology, CancerCare Manitoba

675 McDermot Ave., Winnipeg, Manitoba, Canada, R3E 0V9

eMail: israels@cc.umanitoba.ca