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Synfacts 2010(7): 0842-0842
DOI: 10.1055/s-0029-1220097
DOI: 10.1055/s-0029-1220097
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Paal-Knorr Pyrrole Synthesis Catalyzed by Silica Sulfuric Acid
H. Veisi*
Payame Noor University, Iran
Further Information
Publication History
Publication Date:
22 June 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201007/lookinside/thumbnails/10.1055-s-0029-1220097-1.jpg)
Significance
A simple and efficient method for the preparation of pyrroles from primary amines and γ-diketones by using silica sulfuric acid (SSA) as a heterogeneous acid catalyst was described. The reaction of primary amines with 2,5-hexanedione in the presence of the silica sulfuric acid under solvent-free conditions gave the corresponding substituted pyrroles (65-98% yield, 2-120 min). The reaction conditions were applicable to di- or triamino substrates to afford bipyrrole or tripyrrole compounds.