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Synlett 2010(11): 1685-1687
DOI: 10.1055/s-0029-1219961
DOI: 10.1055/s-0029-1219961
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Botryllamides and Lansiumamides via Ruthenium-Catalyzed Hydroamidation of Alkynes
Further Information
Publication History
Received
26 March 2010
Publication Date:
04 June 2010 (online)


Abstract
Ruthenium-catalyzed hydroamidations of alkynes allow a concise synthetic entry to both E- and Z-configured enamide natural products. This was demonstrated by the synthesis of botryllamides C and E, lansiumamides A and B, and lansamide I in 1-3 steps and 57-98% yield from simple, commercially available precursors.
Key words
alkyne - botryllamide - hydroamidation - lansamide - lansiumamide - ruthenium
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