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Synfacts 2010(6): 0637-0637
DOI: 10.1055/s-0029-1219878
DOI: 10.1055/s-0029-1219878
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Cyclophosphoramidates by Intramolecular C-H Amination
H. Lu*, J. Tao*, J. E. Jones, L. Wojtas, X. P. Zhang*
University of South Florida, Tampa, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219878-1.jpg)
Significance
Reported is a synthesis of six- and seven-membered cyclophosphoramidates by cobalt(II)-catalyzed intramolecular C-H amination effected by phosphoryl azides. A previously reported method for intramolecular amination of carbonyl azides catalyzed by commercially available [Co(TPP)] (TPP: tetraphenylporphyrin) (J. V. Ruppel, R. M. Kamble, X. P. Zhang Org. Lett. 2007, 9, 4889) was found to be ineffective for phosphoryl azide substrates. The success of [Co(II)(Por)] A may be the result of hydrogen-bond interaction between P=O and NH which activates the catalysis.