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Synfacts 2010(6): 0700-0700  
DOI: 10.1055/s-0029-1219769
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Two-Step Transition-Metal-Free Allylation of Grignard Reagents

Contributor(s): Paul Knochel, Andreas J. Wagner
X. Han, Y. Zhang, J. Wu*
Dartmouth College, Hanover, USA
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

A mild two-step procedure for the regioselective, transition-metal-free allylic substitution between Grignard reagents and phosphorothioate esters is reported. The latter are prepared in high yields from the corresponding allylic alcohols or methyl ethers.