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Synfacts 2010(5): 0501-0501  
DOI: 10.1055/s-0029-1219711
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Palau’amine

Contributor(s): Steven V. Ley, Catherine F. Carter
I. B. Seiple, S. Su, I. S. Young, C. A. Lewis, J. Yamaguchi, P. S. Baran*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
22 April 2010 (online)

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Significance

Palau’amine has provided a great synthetic challenge due to its unprecedented trans-5,5-bicycle. The total synthesis was achieved via a transannular ring closure that ­proceeds through amidine tautomer K.