Download PDF
Synfacts 2010(5): 0577-0577  
DOI: 10.1055/s-0029-1219658
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Zinc(II)-Catalyzed Chemoselective Reduction of Amides to Amines

Contributor(s): Paul Knochel, Andrei Gavryushin
S. Das, D. Addis, S. Zhou, K. Junge, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
Further Information

Publication History

Publication Date:
22 April 2010 (online)

   Permissions and Reprints

Significance

The catalytic reduction of amides to amines is a highly desirable transformation in organic synthesis. For the first time, an efficient ­reduction of tertiary amides with unprecedented chemoselectivity and unique tolerance to functional groups is reported. Amides can be selectively reduced in excellent yields in the presence of ester, nitro, cyano, azo substituents, or even a ­ketone.