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Synfacts 2010(4): 0457-0457  
DOI: 10.1055/s-0029-1219590
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

Contributor(s): Paul Knochel, Andrei Gavryushin
D. A. Everson, R. Shrestha, D. J. Weix*
University of Rochester, USA
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Publication History

Publication Date:
22 March 2010 (online)

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Significance

The authors report herein a new, general method for performing direct reductive cross-coupling using a dual ligand-nickel catalytic system. The reaction tolerates a broad number of functional groups and generally offers high yields of products.