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DOI: 10.1055/s-0029-1219573
N,N′-Dimethyl Urea
Publication History
Publication Date:
10 March 2010 (online)
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Introduction
N,N′-Dimethyl urea (DMU) (1,3-dimethyl urea, methyl carbamide) is a colourless solid and a non-volatile, versatile and powerful reagent for the synthesis of nitrogen-containing heterocyclic compounds. It is used for the synthesis of caffeine, theophylline, pharmaceuticals, textile aids, herbicides, etc. It also finds application in metal-ion complexation, material science, etc. In 1954, Blick and Godt synthesized the important building block N,N′-dimethyl-6-amino uracil from a mixture of DMU, cyanoacetic acid, and acetic anhydride with exclusion of moisture under stirring at 60 ˚C for 3 h. [¹] It is a very important starting material for the synthesis of pyrimidine derivatives.
Scheme 1
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