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Synfacts 2010(3): 0314-0314
DOI: 10.1055/s-0029-1219320
DOI: 10.1055/s-0029-1219320
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Gold-Catalyzed Friedel-Crafts Allylic Alkylation of Indoles with Alcohols
M. Bandini*, A. Eichholzer
Universita di Bologna, Italy
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. Februar 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201003/lookinside/thumbnails/10.1055-s-0029-1219320-1.jpg)
Significance
This paper describes a direct chiral bimetallic gold(I)-phosphine complex catalyzed Friedel-Crafts allylic alkylation of indoles with alcohols to give functionalized tetrahydrocarbazoles with good yield and enantioselectivities. A very interesting two-point coordination mode of activation of the allylic alcohol moiety is proposed to account for the success of this reaction.