Synlett 2010(3): 449-452  
DOI: 10.1055/s-0029-1219178
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Alkyne-Terminated PCDA Linker for Applying Click Chemistry on PDA Layers

Ja-Young Namgunga#, Bong-Hyun Junb#, Yoon-Sik Lee*a
a School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea
b School of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-747, Korea
Fax: +82(2)8769625; e-Mail: yslee@snu.ac.kr;
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Received 28 August 2009
Publikationsdatum:
08. Januar 2010 (online)

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Abstract

An alkyne-terminated PCDA (10,12-pentacosadiynoic acid) linker, which can undergo a simple click reaction with azide compounds, was synthesized for the purpose of immobilizing various kinds of biomolecular surface ligands on PDA (polydiacetylene) layers. In order to confirm the ability of the linker compound to anchor azide-modified surface ligands, we carried out a model ­reaction with benzyl azide under typical click-reaction conditions. We were able to confirm that the model reaction proceeded smoothly by observing the color change of PDA, including its thermochromic reversibility.

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