RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000083.xml
Synlett 2010(3): 449-452
DOI: 10.1055/s-0029-1219178
DOI: 10.1055/s-0029-1219178
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Alkyne-Terminated PCDA Linker for Applying Click Chemistry on PDA Layers
Weitere Informationen
Publikationsverlauf
Received
28 August 2009
Publikationsdatum:
08. Januar 2010 (online)


Abstract
An alkyne-terminated PCDA (10,12-pentacosadiynoic acid) linker, which can undergo a simple click reaction with azide compounds, was synthesized for the purpose of immobilizing various kinds of biomolecular surface ligands on PDA (polydiacetylene) layers. In order to confirm the ability of the linker compound to anchor azide-modified surface ligands, we carried out a model reaction with benzyl azide under typical click-reaction conditions. We were able to confirm that the model reaction proceeded smoothly by observing the color change of PDA, including its thermochromic reversibility.
Key words
alkynes - azides - solid-phase synthesis - conjugation - self-assembly
- Supporting Information for this article is available online:
- Supporting Information