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DOI: 10.1055/s-0029-1219163
Solvent-Free Iron(III) Chloride Catalyzed O-, S-, and N-Acylation under Mild Conditions
Publication History
Publication Date:
22 December 2009 (online)
Abstract
An efficient, eco-friendly, and mild method for the acylation of various nucleophiles with acid anhydrides using iron(III) chloride is described. The addition of only 0.1-2 mol% of iron chloride catalyzed the acylation under solvent-free conditions at room temperature to give the acylated products in good yields.
Key words
iron chloride - acylation - solvent-free - alcohols - acid anhydrides
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References and Notes
Typical procedure for iron chloride catalyzed acetylation of alcohols under solvent-free conditions: Iron(III) chloride (0.01 mmol) and acetic anhydride (11 mmol) were placed in a test tube and then kept at room temperature for 10 min in air. Alcohol (10 mmol) was added to the mixture, which was then stirred at room temperature. The crude product was purified by silica gel column chromatography to give the desired acetate.