Synfacts 2010(2): 0184-0184  
DOI: 10.1055/s-0029-1219098
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Lewis Acid Catalyzed Direct Intramolecular Amination of Allylic Alcohols

Contributor(s): Hisashi Yamamoto, Zhi Li
N. Kawai*, R. Abe, J. Uenishi
Kyoto Pharmaceutical University, Japan
Further Information

Publication History

Publication Date:
21 January 2010 (online)

Significance

The authors designed a very efficient Lewis acid catalyzed pathway for the direct intramolecular SN2′ amination of allylic alcohols. The reaction is proposed to undergo a chelation intermediate of bismuth(III) ion and the substrate.