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Synfacts 2010(2): 0131-0131  
DOI: 10.1055/s-0029-1219022
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Alkaloid (±)-G. B. 13

Contributor(s): Philip Kocienski
K. K. Larson, R. Sarpong*
University of California, Berkeley, USA
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Publication History

Publication Date:
21 January 2010 (online)

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Significance

G. B. 13 is one of the 28 Galbuli­mima alkaloids isolated from a tree in Papua New Guinea. Some members of the family (e.g. himbacine) have potentially useful biological activity. The key step in the synthesis depicted is an unprecedented intramolecular rhodium(I)-catalyzed ­hydroarylation reaction (H → I).