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Synthesis 2010(12): 1999-2004  
DOI: 10.1055/s-0029-1218755
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Fluorinated Imines by Addition of Fluoroalkyl Radicals to Conjugated Imines

Masafumi Uedaa, Eri Iwasadaa, Hideto Miyabeb, Okiko Miyata*a, Takeaki Naito*a
a Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan
b School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Chuo-ku, Kobe 650-8530, Japan
Fax: +81(78)4417554; Fax: +81(78)4417642; e-Mail: miyata@kobepharma-u.ac.jp; e-Mail: taknaito@kobepharma-u.ac.jp;
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Publication History

Received 22 February 2010
Publication Date:
23 April 2010 (online)

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Abstract

A novel preparation of β-perfluoroalkyl imine derivatives, useful as synthetic building blocks, was achieved by a route involving addition of electrophilic fluoroalkyl radicals to α,β-unsaturated imines.

Key words

imines - fluoro compounds - addition reactions - radical reactions - fluoroalkylimines

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