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Synthesis 2010(11): 1899-1904
DOI: 10.1055/s-0029-1218752
DOI: 10.1055/s-0029-1218752
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New York
Magnesium Metal-Mediated Reductive Trifluoromethylation of Aldehydes with Phenyl Trifluoromethyl Sulfone
Weitere Informationen
Received
28 February 2010
Publikationsdatum:
23. April 2010 (online)
Publikationsverlauf
Publikationsdatum:
23. April 2010 (online)
![](https://www.thieme-connect.de/media/synthesis/201011/lookinside/thumbnails/10.1055-s-0029-1218752-1.jpg)
Abstract
An unprecedented reductive nucleophilic trifluoromethylation of aldehydes by using phenyl trifluoromethyl sulfone is reported. Mercury(II) chloride efficiently activates magnesium metal to induce the desulfonylative trifluoromethylation process. The new reductive trifluoromethylation provides an alternative method for efficient trifluoromethylation of non-enolizable or enolizable aldehydes with readily available phenyl trifluoromethyl sulfone reagent.
Key words
alkylations - aldehydes - alcohols - trifluoromethylations - phenyl trifluoromethyl sulfone
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