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DOI: 10.1055/s-0029-1218742
Carbon-Fluorine Bond Formation for the Synthesis of Aryl Fluorides
Publication History
Publication Date:
15 April 2010 (online)
Abstract
A selection of carbon-fluorine bond-forming reactions is presented with particular focus on transition-metal-mediated fluorination. A brief summary of conventional fluorination reactions is followed by a discussion of fluorination reactions mediated by palladium and silver. Investigations into the mechanism as well as the conceptual difficulty associated with transition-metal-mediated carbon-fluorine bond formation are presented.
1 Introduction
2 Nucleophilic Fluorination
3 Electrophilic Fluorination
4 Balz-Schiemann Reaction
5 Palladium-Mediated C-X Bond Formation
6 Palladium-Mediated Nucleophilic Fluorination
7 Palladium-Mediated Directed Electrophilic Fluorination
8 Palladium-Mediated Electrophilic Fluorination
9 Silver-Mediated Fluorination
10 Conclusion
Key words
carbon-fluorine bond formation - transition metals - palladium - silver - catalysis
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