A New Synthesis of Functionalized 2,2′-Biimidazoles

Abstract

A new two-step synthesis of N,N′-disubstituted 2,2′-biimidazoles from bisimidoyl chlorides is reported. The bisimidoyl chlorides react smoothly with (2,2-dimethoxyethyl)amine to give bisamidines that are subsequently cyclized to give the corresponding biimidazoles.

Key words

acetals - biimidazole - heterocycles - cyclization - diazadiene complexes

References

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COLLECT, Data Collection Software, Nonius BV: Delft, 1998.

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Crystallographic data for compounds 3b and 5 have been deposited with the Cambridge Crystallographic Data Centre as supplementary publications CCDC-752317 and CCDC-752318, respectively; copies can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: [phone] or email: [e-mail]. uk].