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Synthesis 2010(8): 1311-1314  
DOI: 10.1055/s-0029-1218655
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A New Synthesis of Functionalized 2,2′-Biimidazoles

Kevin Stippicha, Robert Kretschmera, Rainer Beckert*a, Helmar Goerlsb
a Institute of Organic and Macromolecular Chemistry, Humboldtstr. 10, 07743 Jena, Germany
b Institute of Inorganic and Analytical Chemistry, August-Bebel-Str. 2, 07743 Jena, Germany
Fax: +493641948212; e-Mail: Rainer.Beckert@uni-jena.de;
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Publikationsverlauf

Received 12 November 2009
Publikationsdatum:
29. Januar 2010 (online)

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Abstract

A new two-step synthesis of N,N′-disubstituted 2,2′-biimidazoles from bisimidoyl chlorides is reported. The bisimidoyl chlorides react smoothly with (2,2-dimethoxyethyl)amine to give bisamidines that are subsequently cyclized to give the corresponding biimidazoles.

Key words

acetals - biimidazole - heterocycles - cyclization - diazadiene complexes

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