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Synthesis 2010(4): 601-604  
DOI: 10.1055/s-0029-1218592
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of a β-Carboline Scaffold Properly Functionalized for the Generation of Libraries of Bioactive Compounds

Barbara La Ferla*a, Alexandre Orsatoa, Cristiano Zonaa, Giovanni Cervib, Gianluca Papeoc, Eduard R. Felderb, Francesco Nicotraa
a Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Fax: +39(02)64483565; e-Mail: barbara.laferla@unimib.it;
b Chemical Core Technologies, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Italy
c Medicinal Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano, Italy
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Publikationsverlauf

Received 6 November 2009
Publikationsdatum:
07. Dezember 2009 (online)

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Abstract

In this work we report the synthesis of the 1-oxo-1,2,3,4-tetrahydro-β-carboline scaffold with two regioselectively functionalizable positions, starting from a readily available indole precursor.

Key words

β-carboline - scaffold - cyclization - indole - chemoselectivity

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