Synlett 2009(19): 3211-3213  
DOI: 10.1055/s-0029-1218297
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Silver-Catalyzed Intermolecular Hydroamination of Alkenes and 1,3-Dienes

Xavier Giner, Carmen Nájera*
Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain
Fax: +34(96)5903549; e-Mail: cnajera@ua.es;
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Publication History

Received 23 July 2009
Publication Date:
15 October 2009 (online)

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Abstract

Silver triflate is used as efficient catalyst for the intermolecular addition of 4-toluenesulfonamide to alkenes under thermal or microwave heating. The hydroamination of 1,3-dienes can be performed at 85 ˚C with low catalyst loading (0.1-5 mol%) or at room temperature using 1 mol% of AgOTf, the use of HOTf affording similar results.

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