Synthesis of (+)-Haplophytine

H. Ueda; H. Satoh; K. Matsumoto; K. Sugimoto; T. Fukuyama; H. Tokuyama

doi:10.1055/s-0029-1218265

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Synfacts 2010(1): 0003-0003
DOI: 10.1055/s-0029-1218265

Synthesis of Natural Products and Potential Drugs

Synthesis of (+)-Haplophytine

Contributor(s): Philip Kocienski
H. Ueda, H. Satoh, K. Matsumoto, K. Sugimoto, T. Fukuyama*, H. Tokuyama*
Tohoku University, Sendai and University of Tokyo, Japan

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Publication History

Publication Date:
21 December 2009 (online)

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Significance

The first total synthesis of haplophytine features a Friedel-Crafts alkylation to create the quaternary center in D and an oxidative rearrangement F → G → H.