Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(10): 1132-1132
DOI: 10.1055/s-0029-1217921
DOI: 10.1055/s-0029-1217921
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Conjugate Addition to Give Aspartic Acid Derivatives
S. H. Kang, Y. K. Kang, D. Y. Kim*
Soonchunhyang University, Asan, Korea
Further Information
Publication History
Publication Date:
22 September 2009 (online)
Significance
In related work, the groups of Hii and Sodeoka have reported asymmetric addition reactions of aromatic amines to α,β-unsaturated carbonyl compounds such as N-alkenoyl oxazolidinones or N-alkenoyl carbamates catalyzed by cationic BINAP-palladium complexes (Adv. Synth. Catal. 2006, 348, 587; Org. Lett. 2004, 6, 1861). In the present study, the authors utilize dicationic palladium complex 1 in conjugate addition reactions of aromatic amines to fumaryl pyrrolidinone to afford after hydrolysis aspartic acid derivatives in very good yields and enantiomeric ratios.