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Synfacts 2009(10): 1151-1151
DOI: 10.1055/s-0029-1217888
DOI: 10.1055/s-0029-1217888
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Wacker Oxidation of Allylic Phthalimides: A Catalytic Route to β-Amino Acids
B. Weiner, A. Baeza, T. Jerphagnon, B. L. Feringa*
University of Groningen, The Netherlands
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. September 2009 (online)
Significance
The authors report here a new catalytic method for the synthesis of β-amino acids and β-aminoaldehydes via palladium-catalyzed oxidation of protected allylamines as a key step. Together with a simple catalytic enantioselective synthesis of the starting compounds, this method affords a straightforward preparation of a variety of key structural elements of peptidomimetics and natural products.