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Synfacts 2009(10): 1062-1062  
DOI: 10.1055/s-0029-1217869
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Valerenic Acid

Contributor(s): Philip Kocienski, Zofia Komsta
J. Ramharter, J. Mulzer*
University of Vienna, Austria
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Valerenic acid was extracted from the roots of Valeriana officinalis. It is a selective modulator of GABAA receptor subtypes and therefore a potential drug against various central nervous system dysfunctions. The focal step of this short and high-yielding synthesis is an ­intramolecular, metal-coordinated Diels-Alder ­reaction (B → D).