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Synfacts 2009(10): 1112-1112  
DOI: 10.1055/s-0029-1217844
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ru-Catalyzed Asymmetric Transfer Hydrogenation of Heteroaromatic Ketones

Contributor(s): Mark Lautens, Chit Tsui
W.-Y. Shen, Y.-Y. Li, Z.-R. Dong, J.-X. Gao*
Xiamen University, P. R. of China
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Publication History

Publication Date:
22 September 2009 (online)

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Significance

Reported here is an efficient and practical method for synthesizing chiral heteroaromatic alcohols. Asymmetric transfer hydrogenation of the corresponding ketones in isopropanol is achieved, using a chiral diaminodiphosphine-­ruthenium(II) complex 2 as the catalyst. Good yields and enantioselectivities can be obtained in a variety of products. The conditions are non-hazardous and mild causing no reduction of the heterocycle.