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Synthesis 2009(15): 2557-2560
DOI: 10.1055/s-0029-1217398
DOI: 10.1055/s-0029-1217398
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of a Novel Class of Azacrown Macrocycles and Lariat Crown Ethers Containing Two 1,2,4-Triazole Rings as Subunits
Further Information
Received
26 March 2009
Publication Date:
22 June 2009 (online)
Publication History
Publication Date:
22 June 2009 (online)
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Abstract
Azacrown macrocycles were prepared in 70-76% yield by the condensation reaction of 1,2-, 1,3-, and 1,4-bis(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)alkanes with bisaldehydes in acetic acid under reflux. Reaction of two of these azacrown macrocycles with iodomethane and benzyl chloride furnished exclusively the target lariat macrocycles in good yields.
Key words
azacrown macrocycles - 1,2,4-triazole - thiols - bistriazoles - lariat crown ethers
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