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Synthesis 2009(14): 2385-2392  
DOI: 10.1055/s-0029-1217395
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Synthesis of Medium-Sized Heterocycles by Palladium-Catalyzed Intramolecular Heck Reaction via 9-endo-trig Mode of Cyclization

K. C. Majumdar*, Buddhadeb Chattopadhyay
Department of Chemistry, University of Kalyani, Kalyani 741235, West Bengal, India
Fax: +91(33)25828282; e-Mail: kcm_ku@yahoo.co.in;
Further Information

Publication History

Received 8 February 2009
Publication Date:
08 June 2009 (online)

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Abstract

An efficient and high yielding method for the synthesis of nine-membered heterocyclic skeletons has been developed by palladium-catalyzed intramolecular Heck reaction via an unusual 9-endo-trig mode of cyclization.

Key words

intramolecular Heck reaction - palladium acetate - 9-endo-trig - nine-membered ring - Claisen rearrangement

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