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Synthesis 2009(14): 2385-2392
DOI: 10.1055/s-0029-1217395
DOI: 10.1055/s-0029-1217395
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Synthesis of Medium-Sized Heterocycles by Palladium-Catalyzed Intramolecular Heck Reaction via 9-endo-trig Mode of Cyclization
Further Information
Received
8 February 2009
Publication Date:
08 June 2009 (online)
Publication History
Publication Date:
08 June 2009 (online)
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Abstract
An efficient and high yielding method for the synthesis of nine-membered heterocyclic skeletons has been developed by palladium-catalyzed intramolecular Heck reaction via an unusual 9-endo-trig mode of cyclization.
Key words
intramolecular Heck reaction - palladium acetate - 9-endo-trig - nine-membered ring - Claisen rearrangement
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