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Synlett 2009(11): 1737-1740
DOI: 10.1055/s-0029-1217373
DOI: 10.1055/s-0029-1217373
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of 5-Acyl-3,4-dihydropyrimidine-2-thiones via Solvent-Free, Solution-Phase and Solid-Phase Biginelli Procedures
Further Information
Received
20 January 2009
Publication Date:
12 June 2009 (online)
Publication History
Publication Date:
12 June 2009 (online)
![](https://www.thieme-connect.de/media/synlett/200911/lookinside/thumbnails/10.1055-s-0029-1217373-1.jpg)
Abstract
Compounds belonging to the 5-acyl-3,4-dihydropyrimidine-2-thione family were obtained using a solvent-free Biginelli condensation with or without the use of a catalyst. An unprecedented solid-phase procedure involving a polymer-supported aldehyde allowed the preparation of a series of 5-aroyl derivatives starting with crude diketones obtained from their corresponding aryl esters.
Key words
multicomponent reaction - heterocycles - solid-phase synthesis - β-diketones - monastrol
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References and Notes
Present address: The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
2Present address: Hybrigenics, 3-5 Impasse Reille, 75014 Paris, France