Synlett 2009(11): 1791-1794  
DOI: 10.1055/s-0029-1217362
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Propargylamines by Three-Component Coupling of Aldehydes, Amines and Alkynes Catalyzed by Magnetically Separable Copper Ferrite Nanoparticles

M. Lakshmi Kantam*a, Jagjit Yadava, Soumi Lahaa, Shailendra Jhab
a Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India
Fax: +91(40)27160921; e-Mail: mlakshmi@iict.res.in;
b Department of Chemistry, Jadavpur University, 700032 Kolkata, India
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Publikationsdatum:
12. Juni 2009 (online)

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Abstract

An efficient three-component coupling of aldehydes, amines and alkynes has been developed to prepare propargylamines in nearly quantitative yields using magnetically separable copper ferrite nanoparticles as catalyst. Structurally divergent aldehydes and amines were converted into the corresponding propargyl­amines. The reaction does not require any co-catalyst.