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Synfacts 2009(6): 0637-0637  
DOI: 10.1055/s-0029-1217153
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Iridium-Catalyzed Hydrogenation of Enamines

Contributor(s): Mark Lautens, Praew Thansandote
A. Baeza, A. Pfaltz*
University of Basel, Switzerland
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Publication History

Publication Date:
25 May 2009 (online)

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Significance

Complementary to titanocene (N. E. Lee, S. L. Buchwald J. Am. Chem. Soc. 1994, 116, 5985) and rhodium protocols (V. I. Tararov et al. Tetrahedron Lett. 2000, 41, 2351), the present report demonstrates the asymmetric hydrogenation of unfunctionalized enamines using iridium catalysts. These catalysts are composed of chiral oxazoline or pyridine-based N,P-ligands.