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Synthesis 2009(24): 4149-4158  
DOI: 10.1055/s-0029-1217063
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Oxidation of Substituted Pyrrolidines by N-Bromosuccinimide; Rapid Synthesis of Pyrrolo[2,1-a]isoquinolines

Judit Tótha, Linda Váradia, András Dancsób, Gábor Blaskób,1, László Tőkea, Miklós Nyerges*a,1
a Organic Chemical Technology Research Group of the Hungarian Academy of Sciences, Budapest University of Technology and Economics, P.O.B. 91, 1521 Budapest, Hungary
e-Mail: miklos.nyerges@hu.netgrs.com;
b EGIS Pharmaceuticals Ltd., P.O.B. 100, 1475 Budapest, Hungary
Fax: +36(1)8812011;
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Publikationsverlauf

Received 22 July 2009
Publikationsdatum:
19. Oktober 2009 (online)

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Abstract

A new method for converting 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolines into 5,6-dihydropyrrolo[2,1-a]isoquinolines by the use of N-bromosuccinimide as an oxidant is presented.

Key words

azomethine ylides - cycloadditions - oxidation - pyrroles

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1

Present address: Servier Research Institute of Medicinal Chemistry, Záhony utca 7, Graphisoft Park, 1031 Budapest, Hungary.