Synthesis of 1,11-Dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with Potential
Topoisomerase I Inhibitory Activity

Marc Delot; Pascal Carato; Christophe Furman; Amélie Lemoine; Nicolas Lebegue; Pascal Berthelot; Saïd Yous

doi:10.1055/s-0029-1217007

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Synthesis 2009(22): 3819-3822
DOI: 10.1055/s-0029-1217007

PAPER

Synthesis of 1,11-Dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones with Potential Topoisomerase I Inhibitory Activity

Marc Delot^a, Pascal Carato*^a, Christophe Furman*^b, Amélie Lemoine^b, Nicolas Lebegue^a, Pascal Berthelot^a, Saïd Yous^a
^a Faculté de Pharmacie, Laboratoire de Chimie Thérapeutique (EA 1043), Université Lille Nord de France, 3 rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France
^b Institut de Chimie Pharmaceutique Albert Lespagnol (EA 2692), IFR 114, Université Lille Nord de France, 3 rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France
Fax: +3(33)20964913; e-Mail: pascal.carato@univ-lille2.fr;

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Publication History

Received 24 June 2009
Publication Date:
23 September 2009 (online)

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Abstract

A series of 1,11-dihydro-2H-[1,3]oxazolo[4′,5′:5,6]indeno[1,2-b]quinolin-2-ones were prepared by means of Friedländer condensations. The starting materials for the preparations were commercial substituted-2-aminoacetophenones and various 5,6-dihydro-2H-indeno[5,6-d][1,3]oxazole-2,7(3H)-diones that were synthesized from 2(3H)-benzoxazolones or their N-methyl analogues.

Key words

alkaloids - heterocycles - cyclizations - condensation - fused-ring systems

References

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