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Synthesis 2009(18): 3127-3135
DOI: 10.1055/s-0029-1216888
DOI: 10.1055/s-0029-1216888
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Polycyclic Sultams by Palladium-Catalyzed Intramolecular Cyclization
Weitere Informationen
Received
27 April 2009
Publikationsdatum:
07. Juli 2009 (online)
Publikationsverlauf
Publikationsdatum:
07. Juli 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200918/lookinside/thumbnails/10.1055-s-0029-1216888-1.jpg)
Abstract
A practical and high-yielding method for the synthesis of new sultams from readily available sulfonamides, 1-naphthylamine, and 2-halobenzyl bromides is reported. A variety of tricyclic, tetracyclic, and pentacyclic sultams have been prepared via palladium-catalyzed, ligand-free intramolecular cyclization. Detailed mechanistic studies of the reaction pathway are also described.
Keywords
cyclization - palladium acetate - sulfonamides - sultams
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References and Notes
CCDC Ref. No. for the CIF file of 10a: CCDC-693638.