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Synthesis 2009(14): 2333-2340
DOI: 10.1055/s-0029-1216853
DOI: 10.1055/s-0029-1216853
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Novel Procedure for the Synthesis of Benzo[b][1,8]naphthyridine-3-carboxylate Derivatives from Morita-Baylis-Hillman Adduct Acetates
Further Information
Received
2 March 2009
Publication Date:
29 May 2009 (online)
Publication History
Publication Date:
29 May 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200914/lookinside/thumbnails/10.1055-s-0029-1216853-1.jpg)
Abstract
A novel procedure has been designed for the preparation of benzo[b][1,8]naphthyridine-3-carboxylate derivatives from the reaction of Morita-Baylis-Hillman adduct acetates with primary amines, ammonium acetate or benzenesulfonamides. The approach, which involves readily available starting materials and mild reaction conditions, gives excellent yields after a convenient workup procedure.
Key words
benzo[b][1,8]naphthyridine-3-carboxylate - Morita-Baylis-Hillman adduct acetates - primary amines - ammonium acetate - benzenesulfonamides
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