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Synthesis 2009(14): 2345-2348
DOI: 10.1055/s-0029-1216851
DOI: 10.1055/s-0029-1216851
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
The Ullmann Coupling between 2-Chlorobenzoic Acids and Amino Acids; A Valuable Reaction for Preparing 2-Substituted 1-Acetyl-1H-indol-3-yl Acetates
Weitere Informationen
Received
25 February 2009
Publikationsdatum:
29. Mai 2009 (online)
Publikationsverlauf
Publikationsdatum:
29. Mai 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200914/lookinside/thumbnails/10.1055-s-0029-1216851-1.jpg)
Abstract
2-Substituted 3-acetoxy-1-acetyl-1H-indoles were prepared by condensing 2-chlorobenzoic acids with amino acids under Ullmann conditions in good yields, and further cyclodecarboxylation using the Rössing method in moderate to good yields.
Key words
Ullmann coupling - chlorobenzoic acids - amino acids - cyclodecarboxylation - 2-substituted indoles
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