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Synthesis 2009(13): 2146-2154
DOI: 10.1055/s-0029-1216842
DOI: 10.1055/s-0029-1216842
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Efficient and General Preparation of Pyranostilbenes: First Total Synthesis of Artocarbene and Pawhuskin B
Further Information
Received
14 January 2009
Publication Date:
25 May 2009 (online)
Publication History
Publication Date:
25 May 2009 (online)
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Abstract
An efficient and general synthesis providing pyranostilbenes in moderate yields has been developed. It consists of the reaction of pinosylvin with the appropriate α,β-unsaturated aldehyde catalyzed by ethylenediamine diacetate. As an application of this methodology, biologically active natural products artocarbene and pawhuskin B were synthesized by a convergent sequence from commercially available aldehydes.
Key words
heterocycles - alkenes - phenols - artocarbene - pawhuskin B
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