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Synthesis 2009(13): 2184-2204
DOI: 10.1055/s-0029-1216837
DOI: 10.1055/s-0029-1216837
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Four Lysine-Linked Cereulide Analogues Showing Ionophoric Activity Towards Potassium Cations as Lead Compounds for Emetic Toxin-Detection by Immunoassays
Further Information
Received
22 January 2009
Publication Date:
25 May 2009 (online)
Publication History
Publication Date:
25 May 2009 (online)
![](https://www.thieme-connect.de/media/synthesis/200913/lookinside/thumbnails/10.1055-s-0029-1216837-1.jpg)
Abstract
An improved total synthesis of the emetic toxin cereulide and the preparation of four lysine-linked cereulide analogues is described. The cereulide analogues are prepared by replacing one of the amino acid residues in cereulide with lysine. The cereulide analogues demonstrate ionophoric activity towards alkali metal ions and inorganic ammonium ions, and are currently being used to develop an enzyme-linked immunosorbent assay for cereulide.
Key words
cereulide - Bacillus cereus - peptide synthesis - ionophore - l-O-lysine
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