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Synfacts 2009(6): 0626-0626
DOI: 10.1055/s-0029-1216720
DOI: 10.1055/s-0029-1216720
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Protonation through Reactive Chiral Gadolinium Enolates
M. Morita, L. Drouin, R. Motoki, Y. Kimura, I. Fujimori, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
25. Mai 2009 (online)
![](https://www.thieme-connect.de/media/synfacts/200906/lookinside/thumbnails/10.1055-s-0029-1216720-1.jpg)
Significance
The authors have demonstrated that the chiral polynuclear gadolinium complexes derived from L2 and L3 are efficient catalysts for two types of asymmetric protonation reactions: protonation of silyl enol ethers and conjugate cyanation-protonation of N-acyl pyrroles. It is believed that both protonation reactions proceed through chiral gadolinium enolates, which are generated by either protonolysis of silyl enol ethers or conjugate addition of cyanide. Proton source is either bulky phenol or HCN.